Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment in Comorbid Nicotine Addiction with Major Depressive Disorder and Obsessive-Compulsive Disorder

Objective: Nicotine addiction is a common health problem in psychiatric disorders. The aim of this study was to analyze the effects rTMS on comorbid nicotine patients receiving recurrent Transcranial Magnetic Stimulation (rTMS) therapy for major depressive disorder (MDD) and obsessive-compulsive (OCD). Method: Data 32 (23 MDD, 9 OCD) were evaluated retrospectively. We compared Hamilton Depression Rating Scale (HAM-D), Beck Anxiety Inventory (BAS), Yale-Brown Obsession Compulsion (Y-BOCS), Fagerström Test Dependence (FTND) scores at three time points (before treatment "0th week", end “6th week”, 12 weeks after assessment “18th week”). Results: patients’ mean age 40.47±10.20, 13(40.6%) women. A significant reduction found HAM-D, BAS, FTND 6 (p<0.001 all) 18 baseline scores. binary logistic regression showed that changes depression anxiety symptoms not associated with ratings (p=0.158, p=0.251, respectively). Conclusion: In study, it can be said reduces severity accompanying MDD OCD, independent recovery disease. This suggests an effective recommend placebo-controlled randomized double-blind studies.